Bordered on the north by US 24, on the east by I-25 and on the south by US 50. The northwest boundary is an arbitrary line.
- Access from US 285 to the junction with US 24 enters the region near its midpoint and continues to US 50 at Poncha Springs.
- I-25 to US 50 in Pueblo and west to Montrose provides access to the entire region. Not an official scenic byway, but it is worthy of consideration.